You can control the LEDs via midi when the Ableton preset is selected.
That is the simple avenue. Additionally, there is a sysex-way of controlling the Zero which is needed if you want to control text-display. When I tried that sysex mode, I noticed that I lose that "touch-sense" feature which updates the text-content after you touched a different group of controls.
I have not opened it up and I did not intend to, so I don't know whether the axoloti would fit. It's actually a neat idea, I think only that I would be too lazy to try myself.