I am sorry to bump this - but installation on Windows 7 sp1 (at least) certainly does not work as described. Steps to (better not) reproduce:
1) unzipped axo_runtime_win-1.0.12.zip to C:\Program Files (x86)\
verified folder C:\Program Files(x86)\axoloti_runtime\platform_win exists.
2) run axoloti-win-1.0.12.msi (allow to make changes...yes to all, basically). Account has administrative rights but is not the "Administrator" account.
3) plugged Axioloti Core in (and get notification that windows installs the drivers for this device).
Axoloti is plugged in directly - no hub, cable is a data cable.
4) Get notification that "Drivers for this device were not installed correctly".
Axoloti.exe can't connect. In device manager, "Axoloti Bulk Interface" is listed as "other devices" (exclamation mark) - conclusion: won't work like this. Tried uninstalling/re-installing the software several times, plugging into all available (direct) usb ports, nothing else plugged in but mouse/keyboard.
Went down the "releases" on github until I came across "wincompat.zip" (for v 1.06, mind) - unzipped into "Axoloti"-directory, clicked on "update drivers" in device manager, "browse for drivers" - pointed to Axoloti folder (where I unzipped the *.cat and *.inf file to): clicked "Next" - driver installed. Axoloti is now a "generic usb device".
Opening up "Axoloti.exe": it now connects but complains about a CRC mismatch (obviously, due to the different version). Prompt: "Do you want to update the firmware version?" - I declined, as I reckon the 1.0.6 drivers won't work well with 1.0.12 patcher. So what can I do?
As I followed the instructions to the letter, I can definiately say: won't work like this (Windows 7 Ultimate 64bits sp1). Is there an *inf-version of the drivers available for the latest version of Axoloti (1.0.12)? - because they seem to do the trick...